Aase syndrome

or Aase-Smith syndrome is a rare inherited disorder characterized by anemia with some joint and skeletal deformities. Aase syndrome is thought to be an autosomal dominant inherited disorder. The genetic basis of the disease is not known. The anemia is caused by underdevelopment of the bone marrow, which is where blood cells are formed.

It is named after the American paediatricians Jon Morton Aase and David Weyhe Smith.

Symptoms :

+ Mildly slowed growth

+ Pale skin

+ Delayed closure of fontanelles (soft spots)

+ Narrow shoulders

+ Triple jointed thumbs, absent or small knuckles, decreased skin creases at finger joints

+ Inability to fully extend the joints from birth (congenital contractures)

+ Cleft palate

+ Deformed ears

+ Droopy eye lids

Signs and tests :

+ A CBC (complete blood count) will show anemia and a decrease in the white blood cell count.

+ An echocardiogram may reveal heart defects (ventricular septal defect is most common).

+ X-rays will show skeletal abnormalities as described above.

+ A bone marrow biopsy may be performed.

Treatment :

Frequent blood transfusions are given in the first year of life to treat anemia. Prednisone may be given, although this should be avoided in infancy because of side effects on growth and brain development. A bone marrow transplant may be necessary if other treatment fails.